Gastrointestinale Mikroumgebung und die Darm-Lungen-Achse in den Immunantworten von schwerem COVID-19
The worldwide pandemic of coronavirus illness 2019 (COVID-19), brought on by extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented menace to the human well being. A detailed affiliation of the digestive tract is implied by the excessive frequency of gastrointestinal syndromes amongst COVID-19 sufferers. A greater understanding of the function of intestinal microenvironment in COVID-19 immunopathology might be useful to enhance the management of COVID-19 related morbidity and mortality. This assessment summarizes the immune responses related to the severity of COVID-19, the present proof of SARS-CoV-2 intestinal tropism, and the potential involvement of intestine microenvironment in COVID-19 severity. Moreover, we talk about the therapeutic potential of probiotics in its place drugs to stop or alleviate extreme COVID-19 end result.
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AIRE antibody (Ser156) |
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| 70R-34454 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal AIRE antibody (Ser156) |
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AIRE (Phospho-Ser156) Polyclonal Conjugated Antibody |
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| C11782 | SAB | 100ul | EUR 476.4 |
Autoimmune Regulator Phospho-Ser156 (AIRE pS156) Antibody |
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| 20-abx323993 | Abbexa |
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Autoimmune Regulator Phospho-Ser156 (AIRE pS156) Antibody |
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| 20-abx012667 | Abbexa |
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AIRE (Phospho-Ser156) Colorimetric Cell-Based ELISA Kit |
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| EKC2603 | BosterBio | 100ul | EUR 686.4 |
Phospho-AIRE (Ser156) Colorimetric Cell-Based ELISA Kit (OKAG02155) |
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| OKAG02155 | Aviva Systems Biology | 2 x 96 Wells | EUR 888 |
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Description: Description of target: ;Species reactivity: Human: S156;Application: ELISA;Assay info: Assay Type: Cell-Based Subtype: Phospho Detection Method: Colorimetric 450 nm;Sensitivity: |
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anti- Phospho-Akt(Ser473) antibody |
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| FNab06402 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against Phospho-Akt(Ser473) |
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anti- phospho-RCC1(Ser12) antibody |
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| FNab06406 | FN Test | 100µg | EUR 658.5 |
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Description: Antibody raised against phospho-RCC1(Ser12) |
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Phospho- GR (Ser203) Antibody |
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| ABF0042 | Lifescience Market | 100 ug | EUR 525.6 |
Phospho- GR (Ser211) Antibody |
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| ABF2004 | Lifescience Market | 100 ug | EUR 525.6 |
Phospho- GR (Ser226) Antibody |
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| ABF3066 | Lifescience Market | 100 ug | EUR 525.6 |
Phospho- GR (Ser203) Antibody |
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| ABF3067 | Lifescience Market | 100 ug | EUR 525.6 |
Phospho- Rb (Ser608) Antibody |
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| ABF3726 | Lifescience Market | 100 ug | EUR 525.6 |
ATM (Phospho- Ser1981) Antibody |
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| ABF8225 | Lifescience Market | 100 ug | EUR 525.6 |
ATM (Phospho- Ser1981) Antibody |
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| ABF8409 | Lifescience Market | 100 ug | EUR 525.6 |
ATM (Phospho- Ser1987) Antibody |
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| ABF8410 | Lifescience Market | 100 ug | EUR 525.6 |
ATM (Phospho- Ser1981) Antibody |
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| ABF4120 | Lifescience Market | 100 ug | EUR 525.6 |
HSL (Phospho- Ser660) Antibody |
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| ABF8026 | Lifescience Market | 100 ug | EUR 525.6 |
ATM (Phospho- Ser367) Antibody |
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| ABF8099 | Lifescience Market | 100 ug | EUR 525.6 |
ATM (Phospho- Ser183) Antibody |
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| ABF8100 | Lifescience Market | 100 ug | EUR 525.6 |
Met (Phospho- Ser985) Antibody |
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| ABF8121 | Lifescience Market | 100 ug | EUR 525.6 |
KIT (Phospho- Ser746) Antibody |
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| ABF8162 | Lifescience Market | 100 ug | EUR 525.6 |
ZAK (Phospho- Ser165) Antibody |
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| ABF8195 | Lifescience Market | 100 ug | EUR 525.6 |
FAK (Phospho- Ser732) Antibody |
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| ABF8227 | Lifescience Market | 100 ug | EUR 525.6 |
Fos (Phospho- Ser374) Antibody |
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| ABF8270 | Lifescience Market | 100 ug | EUR 525.6 |
p53 (Phospho- Ser392) Antibody |
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| ABF8295 | Lifescience Market | 100 ug | EUR 525.6 |
Tel (Phospho- Ser257) Antibody |
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| ABF8325 | Lifescience Market | 100 ug | EUR 525.6 |
XPA (Phospho- Ser196) Antibody |
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| ABF8335 | Lifescience Market | 100 ug | EUR 525.6 |
BTK (Phospho- Ser179) Antibody |
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| ABF8361 | Lifescience Market | 100 ug | EUR 525.6 |
FAK (Phospho- Ser722) Antibody |
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| ABF8373 | Lifescience Market | 100 ug | EUR 525.6 |
ATM (Phospho- Ser794) Antibody |
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| ABF8411 | Lifescience Market | 100 ug | EUR 525.6 |
Cot (Phospho- Ser400) Antibody |
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| ABF8469 | Lifescience Market | 100 ug | EUR 525.6 |
p73 (Phospho- Ser388) Antibody |
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| ABF8500 | Lifescience Market | 100 ug | EUR 525.6 |
VR1 (Phospho- Ser503) Antibody |
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| ABF8520 | Lifescience Market | 100 ug | EUR 525.6 |
eNOS (Phospho- Ser1179) Antibody |
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| ABF8086 | Lifescience Market | 100 ug | EUR 525.6 |
TIE2 (Phospho- Ser1119) Antibody |
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| ABF8193 | Lifescience Market | 100 ug | EUR 525.6 |
CD91 (Phospho- Ser4520) Antibody |
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| ABF8207 | Lifescience Market | 100 ug | EUR 525.6 |
nNOS (Phospho- Ser1417) Antibody |
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| ABF8231 | Lifescience Market | 100 ug | EUR 525.6 |
MUC1 (Phospho- Ser1227) Antibody |
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| ABF8289 | Lifescience Market | 100 ug | EUR 525.6 |
LRP6 (Phospho- Ser1490) Antibody |
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| ABF8344 | Lifescience Market | 100 ug | EUR 525.6 |
TSC2 (Phospho- Ser1254) Antibody |
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| ABF8354 | Lifescience Market | 100 ug | EUR 525.6 |
IRS2 (Phospho- Ser1100) Antibody |
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| ABF8383 | Lifescience Market | 100 ug | EUR 525.6 |
Phospho- TK (Ser13) Antibody |
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| ABF3068 | Lifescience Market | 100 ug | EUR 525.6 |
RIP3 (Phospho- Ser316 ) Antibody |
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| 12840-100ul | SAB | 100ul | EUR 302.4 |
RIP3 (Phospho- Ser316 ) Antibody |
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| 12840-50ul | SAB | 50ul | EUR 224.4 |
RIP3 (Phospho- Ser339) Antibody |
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| 12841-100ul | SAB | 100ul | EUR 302.4 |
RIP3 (Phospho- Ser339) Antibody |
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| 12841-50ul | SAB | 50ul | EUR 224.4 |
RIP3 (Phospho- Ser304 ) Antibody |
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| 13283-100ul | SAB | 100ul | EUR 302.4 |
RIP3 (Phospho- Ser304 ) Antibody |
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| 13283-50ul | SAB | 50ul | EUR 224.4 |
BACE (Phospho- Ser498) Antibody |
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| ABF8003 | Lifescience Market | 100 ug | EUR 525.6 |
CTIP (Phospho- Ser327) Antibody |
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| ABF8004 | Lifescience Market | 100 ug | EUR 525.6 |
RAD9 (Phospho- Ser272) Antibody |
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| ABF8019 | Lifescience Market | 100 ug | EUR 525.6 |
RhoA (Phospho- Ser188) Antibody |
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| ABF8020 | Lifescience Market | 100 ug | EUR 525.6 |
TLK1 (Phospho- Ser764) Antibody |
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| ABF8029 | Lifescience Market | 100 ug | EUR 525.6 |
RBL2 (Phospho- Ser952) Antibody |
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| ABF8036 | Lifescience Market | 100 ug | EUR 525.6 |
CFTR (Phospho- Ser737) Antibody |
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| ABF8042 | Lifescience Market | 100 ug | EUR 525.6 |
HSF1 (Phospho- Ser307) Antibody |
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| ABF8066 | Lifescience Market | 100 ug | EUR 525.6 |
MAP4 (Phospho- Ser696) Antibody |
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| ABF8075 | Lifescience Market | 100 ug | EUR 525.6 |
PKD2 (Phospho- Ser812) Antibody |
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| ABF8092 | Lifescience Market | 100 ug | EUR 525.6 |
CREB (Phospho- Ser111) Antibody |
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| ABF8109 | Lifescience Market | 100 ug | EUR 525.6 |
eNOS (Phospho- Ser114) Antibody |
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| ABF8111 | Lifescience Market | 100 ug | EUR 525.6 |
eNOS (Phospho- Ser633) Antibody |
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| ABF8112 | Lifescience Market | 100 ug | EUR 525.6 |
LKB1 (Phospho- Ser334) Antibody |
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| ABF8164 | Lifescience Market | 100 ug | EUR 525.6 |
MSK2 (Phospho- Ser196) Antibody |
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| ABF8172 | Lifescience Market | 100 ug | EUR 525.6 |
PKCD (Phospho- Ser664) Antibody |
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| ABF8182 | Lifescience Market | 100 ug | EUR 525.6 |
PKG2 (Phospho- Ser126) Antibody |
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| ABF8184 | Lifescience Market | 100 ug | EUR 525.6 |
RSK3 (Phospho- Ser360) Antibody |
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| ABF8188 | Lifescience Market | 100 ug | EUR 525.6 |
TBK1 (Phospho- Ser172) Antibody |
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| ABF8190 | Lifescience Market | 100 ug | EUR 525.6 |
APLF (Phospho- Ser116) Antibody |
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| ABF8241 | Lifescience Market | 100 ug | EUR 525.6 |
BORA (Phospho- Ser497) Antibody |
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| ABF8249 | Lifescience Market | 100 ug | EUR 525.6 |
CDX2 (Phospho- Ser283) Antibody |
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| ABF8253 | Lifescience Market | 100 ug | EUR 525.6 |
FKHR (Phospho- Ser249) Antibody |
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| ABF8271 | Lifescience Market | 100 ug | EUR 525.6 |
GAIP (Phospho- Ser151) Antibody |
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| ABF8274 | Lifescience Market | 100 ug | EUR 525.6 |
MAP2 (Phospho- Ser136) Antibody |
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| ABF8281 | Lifescience Market | 100 ug | EUR 525.6 |
MLK3 (Phospho- Ser674) Antibody |
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| ABF8288 | Lifescience Market | 100 ug | EUR 525.6 |
PAK6 (Phospho- Ser165) Antibody |
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| ABF8297 | Lifescience Market | 100 ug | EUR 525.6 |
TAB1 (Phospho- Ser438) Antibody |
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| ABF8324 | Lifescience Market | 100 ug | EUR 525.6 |
AKT1 (Phospho- Ser473) Antibody |
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| ABF8355 | Lifescience Market | 100 ug | EUR 525.6 |
AKT1 (Phospho- Ser473) Antibody |
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| ABF8356 | Lifescience Market | 100 ug | EUR 525.6 |
AQP2 (Phospho- Ser261) Antibody |
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| ABF8360 | Lifescience Market | 100 ug | EUR 525.6 |
CDH1 (Phospho- Ser844) Antibody |
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| ABF8365 | Lifescience Market | 100 ug | EUR 525.6 |
CDK5 (Phospho- Ser159) Antibody |
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| ABF8366 | Lifescience Market | 100 ug | EUR 525.6 |
E2F1 (Phospho- Ser364) Antibody |
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| ABF8369 | Lifescience Market | 100 ug | EUR 525.6 |
ETS1 (Phospho- Ser251) Antibody |
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| ABF8371 | Lifescience Market | 100 ug | EUR 525.6 |
ETS1 (Phospho- Ser282) Antibody |
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| ABF8372 | Lifescience Market | 100 ug | EUR 525.6 |
IRF5 (Phospho- Ser437) Antibody |
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| ABF8382 | Lifescience Market | 100 ug | EUR 525.6 |
RBL2 (Phospho- Ser639) Antibody |
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| ABF8401 | Lifescience Market | 100 ug | EUR 525.6 |
CD66 (Phospho- Ser508) Antibody |
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| ABF8414 | Lifescience Market | 100 ug | EUR 525.6 |
Chk2 (Phospho- Ser379) Antibody |
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| ABF8415 | Lifescience Market | 100 ug | EUR 525.6 |
ROR2 (Phospho- Ser449) Antibody |
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| ABF8451 | Lifescience Market | 100 ug | EUR 525.6 |
CD88 (Phospho- Ser327) Antibody |
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| ABF8468 | Lifescience Market | 100 ug | EUR 525.6 |
DRP1 (Phospho- Ser616) Antibody |
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| ABF8470 | Lifescience Market | 100 ug | EUR 525.6 |
EIF6 (Phospho- Ser235) Antibody |
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| ABF8474 | Lifescience Market | 100 ug | EUR 525.6 |
MCM2 (Phospho- Ser139) Antibody |
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| ABF8487 | Lifescience Market | 100 ug | EUR 525.6 |
PNKP (Phospho- Ser114) Antibody |
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| ABF8503 | Lifescience Market | 100 ug | EUR 525.6 |
SYN2 (Phospho- Ser425) Antibody |
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| ABF8514 | Lifescience Market | 100 ug | EUR 525.6 |
TRF2 (Phospho- Ser323) Antibody |
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| ABF8519 | Lifescience Market | 100 ug | EUR 525.6 |
PAK2 (Phospho- Ser141) Antibody |
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| ABF9245 | Lifescience Market | 100 ug | EUR 525.6 |
Gab2 (Phospho- Ser623) Antibody |
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| ABF5427 | Lifescience Market | 100 ug | EUR 525.6 |
Daxx (Phospho- Ser668) Antibody |
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| ABF5441 | Lifescience Market | 100 ug | EUR 525.6 |
IGF2R (Phospho- Ser2484) Antibody |
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| ABF8068 | Lifescience Market | 100 ug | EUR 525.6 |
TOP2A (Phospho- Ser1213) Antibody |
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| ABF8090 | Lifescience Market | 100 ug | EUR 525.6 |
BRCA1 (Phospho- Ser1387) Antibody |
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| ABF8202 | Lifescience Market | 100 ug | EUR 525.6 |
BRCA1 (Phospho- Ser1497) Antibody |
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| ABF8204 | Lifescience Market | 100 ug | EUR 525.6 |
CUTL1 (Phospho- Ser1215) Antibody |
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| ABF8262 | Lifescience Market | 100 ug | EUR 525.6 |
CUTL1 (Phospho- Ser1237) Antibody |
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| ABF8263 | Lifescience Market | 100 ug | EUR 525.6 |
53BP1 (Phospho- Ser1778) Antibody |
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| ABF8337 | Lifescience Market | 100 ug | EUR 525.6 |
PLCG1 (Phospho- Ser1248) Antibody |
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| ABF8390 | Lifescience Market | 100 ug | EUR 525.6 |
TOP2A (Phospho- Ser1337) Antibody |
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| ABF8516 | Lifescience Market | 100 ug | EUR 525.6 |
MAX (Phospho- Ser11) Antibody |
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| ABF8034 | Lifescience Market | 100 ug | EUR 525.6 |
Immunsystem und Methamphetamin: Molekulare Foundation einer Beziehung
Use of methamphetamine (Meth) as a drug of abuse is on the rise worldwide. Moreover its impact on the operate of the mind, Meth has detrimental results on how the immune system capabilities. As documented within the literature, numerous experimental fashions (mobile, animal, mice, and non-human primates) have been used which have contributed to the general data about immune system impairments from Meth publicity. It must be famous that whereas Meth is utilized in very few therapies, it impacts a broad vary of organic mechanisms, not solely immune regulation, in a unfavorable method.
Undoubtfully, the impact of Meth is very complicated; furthermore, the preliminary molecular triggers stay unknown. Analyses of obtainable literature means that the impact of Meth just isn’t prompted by one underlying mechanism. Whether or not the impact of Meth is acute or long-lasting, the general impact is unfavorable. Additional development of our data on Meth’s particular actions would require systematic experimental approaches utilizing all out there fashions. As well as, bioinformatic analyses are crucial to construct a complete mannequin as a wanted software to fill the hole in data.
Fehlende Immunantwort nach mRNA-Impfung gegen SARS-CoV-2 bei einem Patienten mit Organtransplantation
The current approval and distribution of vaccines towards SARS-CoV-2 has been a serious growth within the combat towards the present COVID-19 pandemic. The primary 2 vaccines accredited in the USA, mRNA-1273 and BNT162b2, are each mRNA primarily based and extremely efficient in immunocompetent individuals, however efficacy in sufferers on immunosuppressants has not been established. Moreover, knowledge suggests these sufferers are much less possible that immunocompetent individuals to develop neutralizing antibodies after COVID-19 an infection.
Given the excessive danger of poor outcomes in organ transplant and immunosuppressed sufferers, efficient vaccination is paramount on this group. We current the primary reported case of a SOT affected person who failed to attain seroconversion after 2 doses of mRNA vaccine. This case has important implications about how immunosuppressed sufferers ought to be endorsed about SARS-CoV-2 vaccination and the safety offered. Physicians ought to stay clinically suspicious for an infection with SARS-CoV-2 regardless of vaccination standing in stable organ transplant sufferers. This text is protected by copyright. All rights reserved.
Auswirkungen der Artesunat-Tablette auf die Immunaktivierung und -rekonstitution bei HAART-behandelten Patienten mit unvollständigen Immunantworten
The extent of T cell activation is a greater predictor of CD4+ T cell depletion in extremely energetic anti-retroviral remedy (HAART)-treated sufferers than viral load. Artesunate is an artemisinin by-product that has an immunomodulatory impact. This examine investigated whether or not artesunate pill reduces T cell activation and improves immune reconstitution amongst sufferers with suboptimal immune restoration regardless of receiving long-term efficient HAART. This was a randomized, potential, parallel, open-label trial consisting of 45 individuals whose plasma HIV load was successfully suppressed by HAART for over 18 months and who had CD4+ T cell counts of lower than 300 cells/µL or a rise of lower than 20% from baseline.
The sufferers had been randomized 2:1 into the artesunate group or the management group and acquired artesunate tablets (orally, 50 mg two occasions each day) mixed with HAART or HAART alone, respectively. T-cell subsets, activation markers, scientific signs, viral load and unwanted effects had been assessed. By 48 weeks, artesunate pill didn’t enhance CD4+ T cell restoration or cut back the activation of T cell subsets however induced in a smaller decline within the expression of T cell activation markers amongst HAART-treated sufferers with incomplete immune responses. Nonetheless, artesunate pill did seem to cut back the extent of T cell apoptosis. One topic developed reasonable anaemia. Lengthy-term use of artesunate pill is unlikely to provide substantial scientific advantages in sufferers receiving HAART who exhibit an incomplete immune response.
Induktion von schützenden Immunantworten gegen eine letale Zika-Virus-Herausforderung nach der Impfung mit einem dualen Serotyp des rekombinanten vesikulären Stomatitis-Virus, der das genetisch veränderte Zika-Virus-E-Protein-Gen trägt
The event of a vaccine to stop Zika virus (ZIKV) an infection has been one of many priorities in infectious illness analysis lately. There have been quite a few makes an attempt to develop an efficient vaccine towards ZIKV. It’s crucial to decide on the most secure and the best ZIKV vaccine from all candidate vaccines to manage this an infection globally. Now we have employed a twin serotype of prime-boost recombinant vesicular stomatitis virus (VSV) vaccine technique, to develop a ZIKV vaccine candidate, utilizing a sort 1 IFN-receptor knock-out (Ifnar -/-) mouse mannequin for problem research.
Prime vaccination with an attenuated recombinant VSV Indiana serotype (rVSVInd) carrying a genetically modified ZIKV envelope (E) protein gene adopted by enhance vaccination with attenuated recombinant VSV New Jersey serotype (rVSVNJ) carrying the identical E gene induced sturdy adaptive immune responses. Particularly, rVSV carrying the ZIKV E gene with the honeybee melittin sign peptide (msp) on the N terminus and VSV G protein transmembrane area and cytoplasmic tail (Gtc) on the C terminus of the E gene induced sturdy protecting immune responses. This vaccine routine induced extremely potent neutralizing antibodies and T cell responses within the absence of an adjuvant and guarded Ifnar -/- mice from a deadly dose of the ZIKV problem.
