Influenza is a highly contagious respiratory illness caused by influenza viruses. The virus spreads rapidly, and the World Health Organization estimates that 3-5% of the world’s population gets the flu each year. It can be dangerous, especially for pregnant women, elderly people, young children and people with other illnesses. Intensive care is required in periods of epidemics or pandemics. Generally, influenza is caused by one of three types of viruses: Influenza A, B or C. The WHO says that the virus responsible for most annual epidemics is a variant of type A.
Symptoms generally include fever and the respiratory system, often accompanied by headaches and muscle aches. It can cause mild to severe illness and death may occur in particular cases. Children are at a greater risk than adults of developing complications from influenza infection. People with chronic diseases such as heart disease, diabetes or asthma are also at increased risk.
Flu vaccination is recommended by WHO experts every year to help prevent the spread of infections and to reduce health care expenses related to its treatment. The vaccine consists of antigens (pro
What Influenza A Virions are
Influenza A virions are a type of virus that contains two surface glycoproteins, known as the hemagglutinin (HA) and neuraminidase (NA). These proteins are responsible for the attachment of the virus to cells, as well as the release of newly formed virions from infected cells. HA is also responsible for the majority of the symptoms associated with influenza infection, such as fever, muscle aches, and respiratory distress. NA is responsible for helping the virus spread from cell to cell. Influenza A virions are typically spherical in shape and range in diameter from 80-120 nm. The virion contains a nucleocapsid, which is composed of the viral genome wrapped in a protein coat. The influenza A virions also contain a matrix protein that helps stabilize and arrange the virus’s other components, such as HA and NA, within the host cell. Influenza A virions are capable of infecting both humans and animals, but can only replicate and cause disease in humans.
Influenza B Virions Influenza B Virions Viruses are too small to be seen with the naked eye so scientists must use an electron microscope to observe them. To prepare for observation, samples of viruses must be stained, or colored. This makes it possible for scientists to differentiate between different types of viruses based on their relative sizes and
The Functions of Influenza A Virions
Influenza A virions are responsible for the majority of influenza infections. These virions are unique in that they possess two surface glycoproteins—the hemagglutinin (HA) and neuraminidase (NA).
The primary function of the HA glycoprotein is to attach the virion to cells in the respiratory tract. Once attached, the virion can then begin the process of replication.
The NA glycoprotein, on the other hand, plays a role in helping the virion to spread from cell to cell. It does this by cleaving sialic acid residues, which are found on cell surfaces. This allows the virion to more easily attach to new cells and begin replicating again.
How Influenza A Virions Affect Health
Influenza A virions are responsible for causing a number of serious respiratory illnesses in humans, including the flu. These virions are able to cause illness by binding to and attacking the cells in the respiratory system, which can lead to a number of symptoms such as fever, chest pain, and difficulty breathing. In severe cases, influenza A virions can also cause pneumonia, which can be fatal. While most people recover from an influenza A infection without any long-term effects, some people (particularly young children and the elderly) can develop complications such as bronchitis or ear infections. In very rare cases, influenza A virions can also lead to encephalitis (inflammation of the brain), which can be fatal.
Types of Influenza A Virions
There are four types of influenza A virions, each with a different combination of two surface glycoproteins: hemagglutinin (HA) and neuraminidase (NA). Type A virions are the most common and are responsible for the majority of human infections.
Influenza A Virus Subtype H1N1 Hemagglutinin (H1N1 Hemagglutinin) Antibody | ||||
abx411428-02mg | Abbexa | 0.2 mg | 678 EUR | |
Influenza A Hemagglutinin H1 (A/Brisbane/59/2007)(H1N1) Peptide | ||||
11-563 | ProSci | 0.05 mg | 632.4 EUR | |
Influenza A Hemagglutinin H1 (A/Brisbane/59/2007)(H1N1) Peptide | ||||
11-564 | ProSci | 0.05 mg | 632.4 EUR | |
Influenza A H5N1 Hemagglutinin Peptide | ||||
abx060606-005mg | Abbexa | 0.05 mg | 828 EUR | |
Influenza A H5N1 Hemagglutinin Protein | ||||
abx060607-005mg | Abbexa | 0.05 mg | 811.2 EUR | |
Influenza A H5N1 Hemagglutinin Protein | ||||
abx060609-005mg | Abbexa | 0.05 mg | 811.2 EUR | |
Influenza A (Swine H1N1) Hemagglutinin (A/California/14/2009) Peptide | ||||
11-555 | ProSci | 0.05 mg | 632.4 EUR | |
Recombinant Hemagglutinin Influenza A Virus H1N1 California/06/2009 | ||||
RP-645 | Alpha Diagnostics | 2 ug | 196.8 EUR | |
Avian Influenza A H7N9 Hemagglutinin Peptide | ||||
7821P | ProSci | 0.05 mg | 197.7 EUR | |
Avian Influenza A H7N9 Hemagglutinin Peptide | ||||
7823P | ProSci | 0.05 mg | 197.7 EUR | |
Avian Influenza A H7N9 Hemagglutinin Peptide | ||||
7825P | ProSci | 0.05 mg | 197.7 EUR | |
Avian Influenza A H7N9 Hemagglutinin Antibody | ||||
7821-002mg | ProSci | 0.02 mg | 206.18 EUR | |
Avian Influenza A H7N9 Hemagglutinin Antibody | ||||
7821-01mg | ProSci | 0.1 mg | 523.7 EUR | |
Avian Influenza A H7N9 Hemagglutinin Antibody | ||||
7823-002mg | ProSci | 0.02 mg | 206.18 EUR | |
Avian Influenza A H7N9 Hemagglutinin Antibody | ||||
7823-01mg | ProSci | 0.1 mg | 523.7 EUR | |
Avian Influenza A H7N9 Hemagglutinin Antibody | ||||
7825-002mg | ProSci | 0.02 mg | 206.18 EUR | |
Avian Influenza A H7N9 Hemagglutinin Antibody | ||||
7825-01mg | ProSci | 0.1 mg | 523.7 EUR | |
Avian Influenza H5N1 Hemagglutinin (NT) Antibody | ||||
3909-002mg | ProSci | 0.02 mg | 206.18 EUR | |
Avian Influenza H5N1 Hemagglutinin (NT) Antibody | ||||
3909-01mg | ProSci | 0.1 mg | 523.7 EUR | |
Avian Influenza H5N1 Hemagglutinin (IN1) Antibody | ||||
3911-002mg | ProSci | 0.02 mg | 206.18 EUR | |
Avian Influenza H5N1 Hemagglutinin (IN1) Antibody | ||||
3911-01mg | ProSci | 0.1 mg | 523.7 EUR | |
Avian Influenza H5N1 Hemagglutinin (IN2) Antibody | ||||
3913-002mg | ProSci | 0.02 mg | 206.18 EUR | |
Avian Influenza H5N1 Hemagglutinin (IN2) Antibody | ||||
3913-01mg | ProSci | 0.1 mg | 523.7 EUR | |
Avian Influenza H5N1 Hemagglutinin (IN3) Antibody | ||||
3925-002mg | ProSci | 0.02 mg | 206.18 EUR | |
Avian Influenza H5N1 Hemagglutinin (IN3) Antibody | ||||
3925-01mg | ProSci | 0.1 mg | 523.7 EUR | |
Influenza A H3N2 HA1 Hemagglutinin, HA1 ELISA Kit | ||||
DEIA252 | Creative Diagnostics | 5 plates | 1633.2 EUR | |
Influenza Hemagglutinin (HA) Peptide | ||||
A6004-25 | ApexBio | 25 mg | 633.6 EUR | |
Influenza Hemagglutinin (HA) Peptide | ||||
A6004-5 | ApexBio | 5 mg | 201.6 EUR | |
Influenza Hemagglutinin (HA) Peptide | ||||
A6004-5.1 | ApexBio | 10 mM (in 1mL DMSO) | 560.4 EUR | |
Influenza A Hemagglutinin protein | ||||
80-1405 | Fitzgerald | 100 ug | 3010.8 EUR | |
Hemagglutinin (48-68) /Influenza virus | ||||
5-01291 | CHI Scientific | 4 x 1mg | Ask for price | |
Influenza A Hemagglutinin antibody | ||||
70R-12190 | Fitzgerald | 100 ug | 483.6 EUR | |
Polyclonal Avian Influenza A H7N9 Hemagglutinin Antibody | ||||
APR10994G | Leading Biology | 0.1 mg | 790.8 EUR | |
Polyclonal Avian Influenza A H7N9 Hemagglutinin Antibody | ||||
APR10995G | Leading Biology | 0.1 mg | 790.8 EUR | |
Polyclonal Avian Influenza A H7N9 Hemagglutinin Antibody | ||||
APR10996G | Leading Biology | 0.1 mg | 790.8 EUR | |
Avian Influenza Hemagglutinin Peptide | ||||
3425P | ProSci | 0.05 mg | 197.7 EUR | |
Avian Influenza Hemagglutinin Peptide | ||||
3427P | ProSci | 0.05 mg | 197.7 EUR | |
Influenza A H5N1 (Avian) Hemagglutinin, N-Terminal Peptide | ||||
11-559 | ProSci | 0.05 mg | 645 EUR | |
hemagglutinin (332-340) [Influenza A virus] | ||||
A1141-1 | ApexBio | 1 mg | 129.6 EUR | |
hemagglutinin (332-340) [Influenza A virus] | ||||
A1141-10 | ApexBio | 10 mg | 408 EUR | |
hemagglutinin (332-340) [Influenza A virus] | ||||
A1141-25 | ApexBio | 25 mg | 547.2 EUR | |
hemagglutinin (332-340) [Influenza A virus] | ||||
A1141-5 | ApexBio | 5 mg | 268.8 EUR | |
Avian Influenza Hemagglutinin Antibody | ||||
24276-100ul | SAB | 100ul | 468 EUR | |
Avian Influenza Hemagglutinin Antibody | ||||
24277-100ul | SAB | 100ul | 468 EUR | |
Avian Influenza Hemagglutinin Antibody | ||||
3425-002mg | ProSci | 0.02 mg | 206.18 EUR | |
Avian Influenza Hemagglutinin Antibody | ||||
3427-002mg | ProSci | 0.02 mg | 206.18 EUR | |
Avian Influenza Hemagglutinin Antibody | ||||
3427-01mg | ProSci | 0.1 mg | 523.7 EUR | |
Avian Influenza Hemagglutinin Antibody | ||||
3425-01mg | ProSci | 0.1 mg | 523.7 EUR | |
Influenza A H5N1 (Avian) Hemagglutinin (Middle Region) Peptide | ||||
11-557 | ProSci | 0.05 mg | 632.4 EUR | |
Influenza A H5N1 (Avian) Hemagglutinin (Middle Region) Peptide | ||||
11-558 | ProSci | 0.05 mg | 645 EUR | |
Influenza A virus Hemagglutinin (HA) | ||||
1-CSB-RP189374BA | Cusabio |
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Influenza A virus Hemagglutinin (HA) | ||||
1-CSB-YP356048IBA | Cusabio |
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Influenza A virus Hemagglutinin (HA) | ||||
1-CSB-YP356317IDG | Cusabio |
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Influenza A virus Hemagglutinin (HA) | ||||
1-CSB-EP356317IDG | Cusabio |
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Influenza A virus Hemagglutinin (HA) | ||||
1-CSB-EP607773IER | Cusabio |
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Influenza A virus Hemagglutinin (HA) | ||||
1-CSB-EP714917IEX | Cusabio |
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Influenza A virus Hemagglutinin (HA) | ||||
1-CSB-EP721113IFG | Cusabio |
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Avian Influenza Hemagglutinin 2 Peptide | ||||
3909P | ProSci | 0.05 mg | 197.7 EUR | |
Avian Influenza Hemagglutinin 3 Peptide | ||||
3911P | ProSci | 0.05 mg | 197.7 EUR | |
Avian Influenza Hemagglutinin 4 Peptide | ||||
3913P | ProSci | 0.05 mg | 197.7 EUR | |
Avian Influenza Hemagglutinin 1 Peptide | ||||
3925P | ProSci | 0.05 mg | 197.7 EUR | |
Avian Influenza Hemagglutinin 2 Antibody | ||||
24449-100ul | SAB | 100ul | 468 EUR | |
Avian Influenza Hemagglutinin 3 Antibody | ||||
24450-100ul | SAB | 100ul | 468 EUR | |
Avian Influenza Hemagglutinin 4 Antibody | ||||
24451-100ul | SAB | 100ul | 468 EUR | |
Avian Influenza Hemagglutinin 1 Antibody | ||||
24454-100ul | SAB | 100ul | 468 EUR | |
Recombinant Hemagglutinin Influenza A Virus H5N1 Vietnam 1203/04 | ||||
RP-641 | Alpha Diagnostics | 2 ug | 196.8 EUR | |
Influenza Virus Hemagglutinin Antibody | ||||
abx415742-01mg | Abbexa | 0.1 mg | 944.4 EUR | |
Recombinant Hemagglutinin Influenza A Virus H9N2 Hong Kong 1073/99 | ||||
RP-644 | Alpha Diagnostics | 2 ug | 196.8 EUR | |
Influenza A Hemagglutinin Blocking Peptide | ||||
33R-10998 | Fitzgerald | 50 ug | 229.2 EUR | |
Recombinant Hemagglutinin Influenza A Virus H3N2 Wisconsin 67/05 | ||||
RP-647 | Alpha Diagnostics | 2 ug | 196.8 EUR | |
Recombinant Influenza Hemagglutinin H7 Anhui | ||||
1502-001 | IBT Bioservices | 50ug | 577.2 EUR | |
Recombinant (HEK) Purified Hemagglutinin Influenza A Virus H1N1 H1 (H1N1) (A/New Caledonia/20/99) protein (>95%, his-tag) | ||||
H1N1-01-R-10 | Alpha Diagnostics | 10 ug | 343.2 EUR | |
Recombinant Hemagglutinin Influenza A Virus H7N7 Netherlands 219/03 | ||||
RP-640 | Alpha Diagnostics | 2 ug | 196.8 EUR | |
Recombinant (HEK) Hemagglutinin Influenza A Virus H3N2 Wyoming 3/03 | ||||
RP-643 | Alpha Diagnostics | 2 ug | 196.8 EUR | |
Influenza B Virus Hemagglutinin Antibody | ||||
abx411429-02mg | Abbexa | 0.2 mg | 678 EUR | |
Recombinant Influenza Hemagglutinin H5 Vietnam | ||||
1501-001 | IBT Bioservices | 50ug | 577.2 EUR | |
Influenza A Hemagglutinin Recombinant Protein | ||||
96-374 | ProSci | 0.1 mg | 619.8 EUR | |
Influenza A Hemagglutinin Recombinant Protein | ||||
96-377 | ProSci | 0.1 mg | 619.8 EUR | |
Influenza PR8 Hemagglutinin Peptide (110-119) | ||||
H-6312.0005 | Bachem | 5.0mg | 327.6 EUR | |
Influenza PR8 Hemagglutinin Peptide (110-119) | ||||
H-6312.0025 | Bachem | 25.0mg | 1197.6 EUR | |
Recombinant Influenza hemagglutinin H9 Hong Kong | ||||
1503-001 | IBT Bioservices | 50ug | 577.2 EUR | |
Recombinant Purified Hemagglutinin Influenza A Virus H1N1 H1 (H1N1) (A/New Caledonia/20/99) protein control for Western | ||||
H1N1-01-C | Alpha Diagnostics | 100 ul | 343.2 EUR | |
HA (Influenza A Virus Hemagglutinin) Antibody | ||||
3924-100 | Biovision | each | 379.2 EUR | |
HA (Influenza A Virus Hemagglutinin) Antibody | ||||
3924-30T | Biovision | each | 175.2 EUR | |
Human CellExp? Influenza A [A/Hong Kong/483/97(H5N1)] Hemagglutinin (HA), Recombinant | ||||
P1005-100 | Biovision | each | 1195.2 EUR | |
Human CellExp? Influenza A [A/Hong Kong/483/97(H5N1)] Hemagglutinin (HA), Recombinant | ||||
P1005-20 | Biovision | each | 307.2 EUR | |
Recombinant Influenza hemagglutinin H1 Puerto Rico | ||||
1504-001 | IBT Bioservices | 50ug | 577.2 EUR | |
Recombinant Hemagglutinin Influenza A Virus H1N1 New Caledonia 20/99 (HA protein full length, Sf9 cells) | ||||
RP-638 | Alpha Diagnostics | 2 ug | 196.8 EUR | |
Recombinant Influenza hemagglutinin H10 Jiangxi-Donghu | ||||
1505-001 | IBT Bioservices | 50ug | 577.2 EUR | |
Influenza A Virus Hemagglutinin (HA) Blocking Peptide | ||||
3924BP-50 | Biovision | each | 183.6 EUR | |
hemagglutinin precursor (114-122) amide [Influenza A virus] | ||||
A1142-1 | ApexBio | 1 mg | 129.6 EUR | |
hemagglutinin precursor (114-122) amide [Influenza A virus] | ||||
A1142-10 | ApexBio | 10 mg | 408 EUR | |
hemagglutinin precursor (114-122) amide [Influenza A virus] | ||||
A1142-25 | ApexBio | 25 mg | 547.2 EUR | |
hemagglutinin precursor (114-122) amide [Influenza A virus] | ||||
A1142-5 | ApexBio | 5 mg | 268.8 EUR | |
Mouse anti Influenza A Hemagglutinin H5 Monoclonal Antibody | ||||
DCAB-TJ144 | Creative Diagnostics | 0.1 mg | 1762.8 EUR | |
Recombinant Hemagglutinin Influenza A Virus H3N2 New York 55/04 (HA protein full length, Sf9) | ||||
RP-642 | Alpha Diagnostics | 2 ug | 196.8 EUR | |
Recombinant (HEK) Hemagglutinin Influenza A Virus H3N8 (A/equine/Gansu/7/2008) HA protein (1-344, His-tag, >95%) | ||||
RP-1625 | Alpha Diagnostics | 10 ug | 416.4 EUR | |
Influenza C virus Hemagglutinin-esterase-fusion glycoprotein (HE) | ||||
1-CSB-YP365951IKD | Cusabio |
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Recombinant (HEK) Purified Hemagglutinin Influenza A Virus H3N2 HA1 protein ((H3N2)(A/VICTORIA/210/2009, 19-350 aa, >95%, his-tag) | ||||
H3N2-01-R-10 | Alpha Diagnostics | 10 ug | 343.2 EUR | |
Recombinant (HEK) Purified Hemagglutinin Influenza A Virus H3N2 HA1 protein ((H3N2)(A/VICTORIA/210/2009, 19-350 aa, >95%, his-tag) | ||||
H3N2-01-R-100 | Alpha Diagnostics | 100 ug | 927.6 EUR |
They can be further classified into subtypes based on the particular HA and NA proteins they contain. The four types of influenza A virions are as follows:
Type A1 virions contain the H1N1 proteins and are responsible for the 2009 swine flu pandemic.
Type A2 virions contain the H2N2 proteins and caused the Asian Flu pandemic of 1957.
Type A3 virions contain the H3N2 proteins and are responsible for the majority of human influenza infections today.
Type B virions contain the HBV proteins and cause a less serious form of human influenza.