Beleuchtung molekularer Bahnen bei Multiple

Beleuchtung molekularer Bahnen bei A number of-Sklerose-Läsionen und Immunmechanismus der Matrinenbehandlung bei EAE, einem Mausmodell für MS 

The etiology of a number of sclerosis (MS) is not clear, and the therapy of MS presents an ideal problem. This examine aimed to analyze the pathogenesis and potential therapeutic targets of MS and to outline goal genes of matrine, a quinolizidine alkaloid part derived from the basis of Sophorae flavescens that successfully suppressed experimental autoimmune encephalomyelitis (EAE), an animal mannequin of MS. To this finish, the GSE108000 gene information set within the Gene Expression Omnibus Database, which included 7 power energetic MS lesions and 10 management samples of white matter, was analyzed for differentially expressed genes (DEGs). X cell was used to investigate the microenvironmental variations in mind tissue samples of MS sufferers, together with 64 sorts of immune cells and stromal cells.

The organic features and enriched signaling pathways of DEGs have been analyzed by a number of approaches, together with GO, KEGG, GSEA, and GSVA. The outcomes by X cell confirmed considerably elevated numbers of immune cell populations within the MS lesions, with decreased erythrocytes, megakaryocytes, adipocytes, keratinocytes, endothelial cells, Th1 cells and Tregs. In GSE108000, there have been 637 DEGs, together with 428 up-regulated and 209 down-regulated genes. Potential goal genes of matrine have been then predicted by the community pharmacology methodology of Conventional Chinese language drugs, and 12 key genes have been obtained by cross evaluation of the goal genes of matrine and DEGs in MS lesions.

Lastly, we confirmed by RT-PCR the expected expression of those genes in mind tissues of matrine-treated EAE mice. Amongst these genes, 2 have been considerably downregulated and 6 upregulated by matrine therapy, and the importance of this gene regulation was additional investigated. In conclusion, our examine outlined a number of attainable matrine goal genes, which may be additional elucidated as mechanism(s) of matrine motion, and novel targets within the therapy of MS.

AIRE Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)
LV624567	ABM	1.0 ug DNA	EUR 888

AIRE Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
LV624568	ABM	1.0 ug DNA	EUR 888

AIRN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV718409	ABM	1.0 ug DNA	Ask for price

AIRE Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
LV624569	ABM	1.0 ug DNA	EUR 818.4

AIRE Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)
LV624570	ABM	1.0 ug DNA	EUR 818.4

AIRN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)
LV718410	ABM	1.0 ug DNA	Ask for price

XM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV756071	ABM	1.0 ug DNA	Ask for price

XS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV756089	ABM	1.0 ug DNA	Ask for price

P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV739457	ABM	1.0 ug DNA	Ask for price

S7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV747677	ABM	1.0 ug DNA	Ask for price

CS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV709011	ABM	1.0 ug DNA	EUR 379.2

IV Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV730175	ABM	1.0 ug DNA	Ask for price

NA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV735845	ABM	1.0 ug DNA	Ask for price

NM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV736283	ABM	1.0 ug DNA	Ask for price

MS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV734267	ABM	1.0 ug DNA	Ask for price

C5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV704421	ABM	1.0 ug DNA	EUR 540

HP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV703719	ABM	1.0 ug DNA	EUR 540

NP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV814299	ABM	1.0 ug DNA	EUR 540

TYS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV754913	ABM	1.0 ug DNA	Ask for price

VCF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755573	ABM	1.0 ug DNA	Ask for price

VDI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755609	ABM	1.0 ug DNA	Ask for price

WSN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755987	ABM	1.0 ug DNA	Ask for price

WT2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755993	ABM	1.0 ug DNA	Ask for price

WTS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755999	ABM	1.0 ug DNA	Ask for price

WWS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV756017	ABM	1.0 ug DNA	Ask for price

XCE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV756041	ABM	1.0 ug DNA	Ask for price

XGR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV756047	ABM	1.0 ug DNA	Ask for price

XIC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV756059	ABM	1.0 ug DNA	Ask for price

RSS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV747629	ABM	1.0 ug DNA	Ask for price

S11 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV747683	ABM	1.0 ug DNA	Ask for price

S12 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV747689	ABM	1.0 ug DNA	Ask for price

SDU Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV748127	ABM	1.0 ug DNA	Ask for price

SEA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV748133	ABM	1.0 ug DNA	Ask for price

RP6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV747185	ABM	1.0 ug DNA	Ask for price

PRD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV741569	ABM	1.0 ug DNA	Ask for price

PRS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV741749	ABM	1.0 ug DNA	Ask for price

PDR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV739871	ABM	1.0 ug DNA	Ask for price

PIH Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV740315	ABM	1.0 ug DNA	Ask for price

mF4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV732743	ABM	1.0 ug DNA	Ask for price

CPP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV759281	ABM	1.0 ug DNA	EUR 2148

CPQ Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV759287	ABM	1.0 ug DNA	EUR 686.4

FTX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV761753	ABM	1.0 ug DNA	EUR 1104

LY9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV705291	ABM	1.0 ug DNA	EUR 540

DUT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV705459	ABM	1.0 ug DNA	EUR 540

NPL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV705585	ABM	1.0 ug DNA	EUR 540

BMF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV705639	ABM	1.0 ug DNA	EUR 540

FTO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV705999	ABM	1.0 ug DNA	EUR 540

MIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV706503	ABM	1.0 ug DNA	EUR 540

ATD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV719171	ABM	1.0 ug DNA	Ask for price

GCY Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV726557	ABM	1.0 ug DNA	Ask for price

GTS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV727145	ABM	1.0 ug DNA	Ask for price

CCT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV720665	ABM	1.0 ug DNA	Ask for price

CCV Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV720719	ABM	1.0 ug DNA	Ask for price

CHR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV721169	ABM	1.0 ug DNA	Ask for price

HPT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV728723	ABM	1.0 ug DNA	Ask for price

HTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV728969	ABM	1.0 ug DNA	Ask for price

HMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV728375	ABM	1.0 ug DNA	Ask for price

F7R Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV724757	ABM	1.0 ug DNA	Ask for price

FND Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV725471	ABM	1.0 ug DNA	Ask for price

CMM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV721403	ABM	1.0 ug DNA	Ask for price

CNC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV721451	ABM	1.0 ug DNA	Ask for price

COP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV721595	ABM	1.0 ug DNA	Ask for price

CRG Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV721781	ABM	1.0 ug DNA	Ask for price

CRS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV721793	ABM	1.0 ug DNA	Ask for price

CSE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV721835	ABM	1.0 ug DNA	Ask for price

CTD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV721919	ABM	1.0 ug DNA	Ask for price

DCE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV722333	ABM	1.0 ug DNA	Ask for price

DDU Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV722357	ABM	1.0 ug DNA	Ask for price

DWS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV723515	ABM	1.0 ug DNA	Ask for price

EBM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV723683	ABM	1.0 ug DNA	Ask for price

EGI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV723929	ABM	1.0 ug DNA	Ask for price

DM1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV723179	ABM	1.0 ug DNA	Ask for price

MPI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712365	ABM	1.0 ug DNA	EUR 379.2

TK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV715875	ABM	1.0 ug DNA	EUR 379.2

TTK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV716385	ABM	1.0 ug DNA	EUR 379.2

UBB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV716529	ABM	1.0 ug DNA	EUR 379.2

WAC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV716727	ABM	1.0 ug DNA	EUR 379.2

AFA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV718313	ABM	1.0 ug DNA	Ask for price

AIC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV718391	ABM	1.0 ug DNA	Ask for price

AOM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV718865	ABM	1.0 ug DNA	Ask for price

PTS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV713985	ABM	1.0 ug DNA	EUR 379.2

RGR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV714303	ABM	1.0 ug DNA	EUR 379.2

Sp2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV715317	ABM	1.0 ug DNA	EUR 379.2

Sp2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV715323	ABM	1.0 ug DNA	EUR 379.2

Syk Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV715605	ABM	1.0 ug DNA	EUR 379.2

HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV701979	ABM	1.0 ug DNA	EUR 540

C8A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV702501	ABM	1.0 ug DNA	EUR 540

EVL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV709839	ABM	1.0 ug DNA	EUR 379.2

FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710247	ABM	1.0 ug DNA	EUR 379.2

FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710253	ABM	1.0 ug DNA	EUR 379.2

FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710259	ABM	1.0 ug DNA	EUR 379.2

FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710265	ABM	1.0 ug DNA	EUR 379.2

FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710271	ABM	1.0 ug DNA	EUR 379.2

FUZ Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710289	ABM	1.0 ug DNA	EUR 379.2

GIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710403	ABM	1.0 ug DNA	EUR 379.2

GRN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710661	ABM	1.0 ug DNA	EUR 379.2

CGA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV708669	ABM	1.0 ug DNA	EUR 379.2

CKB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV708753	ABM	1.0 ug DNA	EUR 379.2

CRK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV708987	ABM	1.0 ug DNA	EUR 379.2

CRP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV708993	ABM	1.0 ug DNA	EUR 379.2

CRP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV708999	ABM	1.0 ug DNA	EUR 379.2

DTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV709467	ABM	1.0 ug DNA	EUR 379.2

NF2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712731	ABM	1.0 ug DNA	EUR 379.2

NMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712773	ABM	1.0 ug DNA	EUR 379.2

OAT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712983	ABM	1.0 ug DNA	EUR 379.2

OS9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV713019	ABM	1.0 ug DNA	EUR 379.2

PIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV713469	ABM	1.0 ug DNA	EUR 379.2

HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710829	ABM	1.0 ug DNA	EUR 379.2

HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV710835	ABM	1.0 ug DNA	EUR 379.2

HYI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV711141	ABM	1.0 ug DNA	EUR 379.2

JTB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV711555	ABM	1.0 ug DNA	EUR 379.2

LBH Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV711897	ABM	1.0 ug DNA	EUR 379.2

LTF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712071	ABM	1.0 ug DNA	EUR 379.2

LUM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712083	ABM	1.0 ug DNA	EUR 379.2

LXN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712089	ABM	1.0 ug DNA	EUR 379.2

MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712167	ABM	1.0 ug DNA	EUR 379.2

MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712173	ABM	1.0 ug DNA	EUR 379.2

MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712179	ABM	1.0 ug DNA	EUR 379.2

MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV712185	ABM	1.0 ug DNA	EUR 379.2

OED Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV736703	ABM	1.0 ug DNA	Ask for price

KSS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV730745	ABM	1.0 ug DNA	Ask for price

KWE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV730751	ABM	1.0 ug DNA	Ask for price

LCO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV730883	ABM	1.0 ug DNA	Ask for price

JBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV730193	ABM	1.0 ug DNA	Ask for price

JPD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV730199	ABM	1.0 ug DNA	Ask for price

KFM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV730349	ABM	1.0 ug DNA	Ask for price

KMS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV730469	ABM	1.0 ug DNA	Ask for price

NSX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV736493	ABM	1.0 ug DNA	Ask for price

NT3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV736499	ABM	1.0 ug DNA	Ask for price

OAP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV736655	ABM	1.0 ug DNA	Ask for price

MAA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV732365	ABM	1.0 ug DNA	Ask for price

MCO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV732641	ABM	1.0 ug DNA	Ask for price

MEB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV732671	ABM	1.0 ug DNA	Ask for price

MPE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV733739	ABM	1.0 ug DNA	Ask for price

MSD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV734285	ABM	1.0 ug DNA	Ask for price

MLS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV733631	ABM	1.0 ug DNA	Ask for price

MOK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV733685	ABM	1.0 ug DNA	Ask for price

AEN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV707157	ABM	1.0 ug DNA	EUR 379.2

AEN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV707163	ABM	1.0 ug DNA	EUR 379.2

AGK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV707187	ABM	1.0 ug DNA	EUR 379.2

ALB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV707271	ABM	1.0 ug DNA	EUR 379.2

ANG Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV707325	ABM	1.0 ug DNA	EUR 379.2

ATM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV707655	ABM	1.0 ug DNA	EUR 379.2

BID Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV707847	ABM	1.0 ug DNA	EUR 379.2

BMF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV707871	ABM	1.0 ug DNA	EUR 379.2

BMF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV707877	ABM	1.0 ug DNA	EUR 379.2

CA8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV708255	ABM	1.0 ug DNA	EUR 379.2

CA8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV708261	ABM	1.0 ug DNA	EUR 379.2

CBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV708339	ABM	1.0 ug DNA	EUR 379.2

CBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV708345	ABM	1.0 ug DNA	EUR 379.2

FGA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV704103	ABM	1.0 ug DNA	EUR 540

NNT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV704253	ABM	1.0 ug DNA	EUR 379.2

SLN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV702969	ABM	1.0 ug DNA	EUR 540

CRP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV703479	ABM	1.0 ug DNA	EUR 540

NPL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV703695	ABM	1.0 ug DNA	EUR 540

LY9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV703815	ABM	1.0 ug DNA	EUR 540

TDD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV750293	ABM	1.0 ug DNA	Ask for price

THM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV750401	ABM	1.0 ug DNA	Ask for price

TOC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV750677	ABM	1.0 ug DNA	Ask for price

ST2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV749651	ABM	1.0 ug DNA	EUR 686.4

ST3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV749657	ABM	1.0 ug DNA	Ask for price

ST4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV749669	ABM	1.0 ug DNA	Ask for price

ST8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV749687	ABM	1.0 ug DNA	Ask for price

TKT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV807481	ABM	1.0 ug DNA	EUR 379.2

TKT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV807487	ABM	1.0 ug DNA	EUR 379.2

DCI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV809319	ABM	1.0 ug DNA	EUR 379.2

RIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV812619	ABM	1.0 ug DNA	EUR 379.2

HNT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV812739	ABM	1.0 ug DNA	EUR 379.2

GAS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV813447	ABM	1.0 ug DNA	EUR 379.2

NMB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV792189	ABM	1.0 ug DNA	EUR 379.2

RET Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV792597	ABM	1.0 ug DNA	EUR 379.2

SFN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV792783	ABM	1.0 ug DNA	EUR 379.2

PB1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV811119	ABM	1.0 ug DNA	EUR 379.2

GBL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV811197	ABM	1.0 ug DNA	EUR 379.2

UTX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV814419	ABM	1.0 ug DNA	EUR 540

PB1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV815385	ABM	1.0 ug DNA	EUR 540

NLP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV811935	ABM	1.0 ug DNA	EUR 379.2

DCI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV812301	ABM	1.0 ug DNA	EUR 379.2

TYRL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV754907	ABM	1.0 ug DNA	Ask for price

UBL6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755087	ABM	1.0 ug DNA	Ask for price

UGP1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755123	ABM	1.0 ug DNA	Ask for price

VIS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755621	ABM	1.0 ug DNA	Ask for price

VMD1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755627	ABM	1.0 ug DNA	Ask for price

VRNI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755849	ABM	1.0 ug DNA	Ask for price

VTNR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755879	ABM	1.0 ug DNA	Ask for price

WBS2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
LV755915	ABM	1.0 ug DNA	Ask for price

Fibroblasten als Immunregulatoren bei Infektionen, Entzündungen und Krebs

cells behave, with tissue-resident fibroblasts rising as a key cell kind in regulating activation or suppression of an immune response. Fibroblasts are heterogeneous cells, encompassing functionally distinct populations, the phenotypes of which differ in accordance with their tissue of origin and sort of inciting illness. Their immunological properties are additionally numerous, starting from the upkeep of a potent inflammatory surroundings in power irritation to selling immunosuppression in malignancy, and encapsulating and incarcerating infectious brokers inside tissues.

On this Evaluate, we examine the mechanisms by which fibroblasts management native immune responses, in addition to the elements regulating their inflammatory and suppressive profiles, in several tissues and pathological settings. This cross-disease perspective highlights the significance of tissue context in figuring out fibroblast-immune cell interactions, in addition to potential therapeutic avenues to exploit this data for the advantage of sufferers with power an infection, irritation and most cancers.

Ibrutinib hat zeitabhängige On- und Off-Goal-Effekte auf Plasma-Biomarker und Immunzellen bei chronischer lymphatischer Leukämie 

Ibrutinib is a covalently binding inhibitor of the B-cell receptor signaling-mediator Bruton’s tyrosine kinase (BTK) with nice efficacy in power lymphocytic leukemia (CLL). Frequent unwanted effects like atrial fibrillation (AF), bleeding and infections may be brought on by ibrutinib’s inhibition of different kinases in non-B cells. 5-year follow-up of plasma biomarkers by proximity extension assay and immune cell numbers by circulate cytometry throughout ibrutinib therapy revealed that 86 of the 265 investigated plasma biomarkers considerably modified throughout therapy, 74 of which decreased.

Among the many 12 markers that elevated, 6 are related to cardiovascular ailments and subsequently doubtlessly concerned in ibrutinib-induced AF. Comparability between wholesome donors and X-linked agammaglobulinemia (XLA) sufferers, who’ve nonfunctional BTK and primarily lack B cells, confirmed indicative adjustments in 53 of the 265 biomarkers whereas none differed considerably. Therefore, neither B cells nor BTK-dependent pathways in different cells appear to affect the degrees of the studied plasma biomarkers in wholesome donors.

Concerning immune cells, absolutely the variety of T cells, together with subsets, decreased, paralleling the reducing tumor burden. T helper 1 (Th1) cell numbers dropped strongly, whereas Th2 cells remained comparatively secure, inflicting Th2-skewing. Thus, long-term ibrutinib therapy has a profound impression on the plasma proteome and immune cells in sufferers with CLL.

Analyse der Immunantworten auf abgeschwächtes Alcelaphin-Herpesvirus 1, formuliert mit und ohne Adjuvans 

The experimental vaccine for bovine malignant catarrhal fever consists of viable attenuated alcelaphine herpesvirus 1 (AlHV-1) derived by intensive tradition passage, mixed with an oil-in-water adjuvant, delivered intramuscularly. This immunisation technique was over 80% efficient in earlier experimental and area trials and safety seemed to be related to induction of virus-neutralising antibodies. Whether or not the vaccine virus is required to be viable on the level of immunisation and whether or not adjuvant is required to induce the suitable immune responses stays unclear.

To handle these points two research have been carried out, firstly to analyse immune responses within the presence and absence of adjuvant and secondly, to analyze immune responses to vaccines containing adjuvant plus viable or inactivated AlHV-1. The primary examine confirmed that viable attenuated AlHV-1 within the absence of adjuvant induced virus-specific antibodies however the titres of virus-neutralising antibodies have been considerably decrease than these induced by vaccine containing viable virus and adjuvant, suggesting adjuvant was required for optimum responses.

In distinction, the second examine discovered that the vaccine containing inactivated (>99.9%) AlHV-1 induced comparable ranges of virus-neutralising antibody to the equal formulation containing viable AlHV-1. Collectively these research recommend that the MCF vaccine acts as an antigen depot for induction of immune responses, requiring adjuvant and an acceptable antigen supply, which needn’t be viable virus. These observations could assist in directing the growth of other MCF vaccine formulations for distribution within the absence of an intensive chilly chain.

AIRE Antibody
ABD6603	Lifescience Market	100 ug	EUR 525.6

AIRE Antibody
AF0334	Affbiotech	200ul	EUR 420

AIRE Antibody
32424-100ul	SAB	100ul	EUR 302.4

AIRE Antibody
33590-100ul	SAB	100ul	EUR 302.4

AIRE Antibody
33590-50ul	SAB	50ul	EUR 224.4

AIRE Antibody
AF6841	Affbiotech	100ul	EUR 420

AIRE Antibody
1-CSB-PA001502HA01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

AIRE Antibody
CSB-PA001502KA01HU-	Cusabio	each	EUR 402
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

AIRE Antibody
CSB-PA001502KA01HU-100ul	Cusabio	100ul	EUR 466.8
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

AIRE Antibody
1-CSB-PA000839	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/10000

AIRE Antibody
1-CSB-PA009261	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

AIRE Antibody
CSB-PA274868-	Cusabio	each	EUR 402
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

AIRE Antibody
CSB-PA274868-100ul	Cusabio	100ul	EUR 379.2
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

AIRE Antibody
DF6603	Affbiotech	200ul	EUR 420

AIRE Antibody
DF3026	Affbiotech	200ul	EUR 420

AIRE Antibody
R32465	NSJ Bioreagents	100 ug	EUR 356.15
Description: The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

AIRE Antibody
R34350-100UG	NSJ Bioreagents	100 ug	EUR 339.15
Description: Additional name(s) for this target protein: Autoimmune regulator protein

AIRE Antibody
R34389-100UG	NSJ Bioreagents	100 ug	EUR 339.15
Description: Additional name(s) for this target protein: Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), APECED

AIRE Antibody
R35463-100UG	NSJ Bioreagents	100 ug	EUR 339.15
Description: Additional name(s) for this target protein: Autoimmune regulator, APECED, Automimmune polyendocrinopathy candidiasis ectodermal dystrophy

Anti-AIRE/Aire 1 Antibody
A00558	BosterBio	100ul	EUR 476.4
Description: Rabbit Polyclonal AIRE/Aire 1 Antibody. Validated in IF, WB and tested in Human, Mouse.

anti- AIRE antibody
FNab00241	FN Test	100µg	EUR 606.3
Description: Antibody raised against AIRE

AIRE antibody (Ser156)
70R-34454	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal AIRE antibody (Ser156)

Polyclonal AIRE Antibody
APR03336G	Leading Biology	0.05ml	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AIRE . This antibody is tested and proven to work in the following applications:

AIRE Antibody, HRP conjugated
1-CSB-PA001502HB01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

AIRE Antibody, FITC conjugated
1-CSB-PA001502HC01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

AIRE (pS156) Antibody
abx332932-100ul	Abbexa	100 ul	EUR 560.4

AIRE Antibody, Biotin conjugated
1-CSB-PA001502HD01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against AIRE. Recognizes AIRE from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Polyclonal AIRE Antibody (Internal)
APG00998G	Leading Biology	0.05mg	EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human AIRE (Internal). This antibody is tested and proven to work in the following applications:

Autoimmune regulator (AIRE) Antibody
48129-100ul	SAB	100ul	EUR 399.6

Autoimmune regulator (AIRE) Antibody
48129-50ul	SAB	50ul	EUR 286.8

Autoimmune regulator (AIRE) Antibody
48149-100ul	SAB	100ul	EUR 399.6

Autoimmune regulator (AIRE) Antibody
48149-50ul	SAB	50ul	EUR 286.8

Autoimmune Regulator (AIRE) Antibody
abx230241-100ug	Abbexa	100 ug	EUR 577.2

Autoimmune Regulator (AIRE) Antibody
20-abx312575	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Autoimmune Regulator (AIRE) Antibody
20-abx171376	Abbexa	EUR 1028.40 EUR 526.80	1 mg 200 ug

Autoimmune Regulator (AIRE) Antibody
20-abx325675	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Autoimmune Regulator (AIRE) Antibody
20-abx323992	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Autoimmune Regulator (AIRE) Antibody
20-abx013298	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

Autoimmune Regulator (AIRE) Antibody
abx038141-100ug	Abbexa	100 ug	EUR 469.2

Autoimmune Regulator (AIRE) Antibody
abx019018-100ug	Abbexa	100 ug	EUR 410.4

Autoimmune Regulator (AIRE) Antibody
20-abx007582	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Autoimmune Regulator (AIRE) Antibody
20-abx001466	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Autoimmune Regulator (AIRE) Antibody
20-abx175527	Abbexa	EUR 1446.00 EUR 693.60	1 mg 200 ug

Autoimmune Regulator (AIRE) Antibody
20-abx175528	Abbexa	EUR 1479.60 EUR 710.40	1 mg 200 ug

Autoimmune Regulator (AIRE) Antibody
20-abx175529	Abbexa	EUR 1479.60 EUR 710.40	1 mg 200 ug

Autoimmune Regulator (AIRE) Antibody
abx117155-100ug	Abbexa	100 ug	EUR 560.4

Autoimmune Regulator (AIRE) Antibody
abx331461-100ul	Abbexa	100 ul	EUR 510

AIRE Conjugated Antibody
C32424	SAB	100ul	EUR 476.4

AIRE-1 Polyclonal Antibody
ABP50619-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of AIRE-1 from Human, Mouse. This AIRE-1 antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AIRE-1 at AA range: 60-140

AIRE-1 Polyclonal Antibody
ABP50619-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of AIRE-1 from Human, Mouse. This AIRE-1 antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AIRE-1 at AA range: 60-140

AIRE-1 Polyclonal Antibody
ABP50619-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of AIRE-1 from Human, Mouse. This AIRE-1 antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AIRE-1 at AA range: 60-140

AIRE-1 Polyclonal Antibody
ABP54773-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of AIRE-1 from Human. This AIRE-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156

AIRE-1 Polyclonal Antibody
ABP54773-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of AIRE-1 from Human. This AIRE-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156

AIRE-1 Polyclonal Antibody
ABP54773-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of AIRE-1 from Human. This AIRE-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156

AIRE-1 Polyclonal Antibody
40562-100ul	SAB	100ul	EUR 302.4

AIRE-1 Polyclonal Antibody
40562-50ul	SAB	50ul	EUR 224.4

AIRE-1 Polyclonal Antibody
ES1618-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

AIRE-1 Polyclonal Antibody
ES1618-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

AIRE-1 Polyclonal Antibody
ES5772-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

AIRE-1 Polyclonal Antibody
ES5772-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against AIRE-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AIRE Antibody (C-Terminus)
APG00997G	Leading Biology	0.05mg	EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human AIRE (C-Terminus). This antibody is tested and proven to work in the following applications:

Autoimmune Regulator (AIRE) Antibody (HRP)
20-abx312576	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

AIRE (Isoform 1) Antibody
abx432298-200ul	Abbexa	200 ul	EUR 460.8

Autoimmune Regulator (AIRE) Antibody (FITC)
20-abx312577	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Autoimmune Regulator (AIRE) Antibody (Biotin)
20-abx312578	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

AIRE (Phospho-Ser156) Antibody
11782-100ul	SAB	100ul	EUR 302.4

AIRE (Phospho-Ser156) Antibody
11782-50ul	SAB	50ul	EUR 224.4

AIRE-1 Polyclonal Conjugated Antibody
C40562	SAB	100ul	EUR 476.4

AIRE (Isoforms 1 + 2) Antibody
abx431084-200ul	Abbexa	200 ul	EUR 460.8

AIRE-1 (phospho Ser156) Polyclonal Antibody
ABP54772-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of AIRE-1 phospho Ser156) from Human. This AIRE-1 phospho Ser156) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the phosphorylation site of S156

AIRE-1 (phospho Ser156) Polyclonal Antibody
ABP54772-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of AIRE-1 phospho Ser156) from Human. This AIRE-1 phospho Ser156) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the phosphorylation site of S156

AIRE-1 (phospho Ser156) Polyclonal Antibody
ABP54772-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of AIRE-1 phospho Ser156) from Human. This AIRE-1 phospho Ser156) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AIRE-1 around the phosphorylation site of S156

AIRE-1 (phospho Ser156) Polyclonal Antibody
ES5771-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against AIRE-1 (phospho Ser156) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

AIRE-1 (phospho Ser156) Polyclonal Antibody
ES5771-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against AIRE-1 (phospho Ser156) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

AIRE (Isoforms 1 and 2) Antibody
abx432299-200ul	Abbexa	200 ul	EUR 460.8

Autoimmune regulator (AIRE) Conjugated Antibody
C48129	SAB	100ul	EUR 476.4

AIRE (Phospho-Ser156) Polyclonal Conjugated Antibody
C11782	SAB	100ul	EUR 476.4

AIRE siRNA
20-abx907108	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

AIRE siRNA
20-abx907109	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

Autoimmune Regulator Phospho-Ser156 (AIRE pS156) Antibody
20-abx323993	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Autoimmune Regulator Phospho-Ser156 (AIRE pS156) Antibody
20-abx012667	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

AIRE Peptide
45-225P	ProSci	0.1 mg	EUR 405.6
Description: (CT) AIRE Peptide

AIRE Peptide
45-226P	ProSci	0.1 mg	EUR 405.6
Description: (IN) AIRE Peptide

AIRE Peptide
45-227P	ProSci	0.1 mg	EUR 405.6
Description: (IN) AIRE Peptide

AIRE Rabbit pAb
A1767-100ul	Abclonal	100 ul	EUR 369.6

AIRE Rabbit pAb
A1767-200ul	Abclonal	200 ul	EUR 550.8

AIRE Rabbit pAb
A1767-20ul	Abclonal	20 ul	EUR 219.6

AIRE Rabbit pAb
A1767-50ul	Abclonal	50 ul	EUR 267.6

AIRE Rabbit pAb
A14183-100ul	Abclonal	100 ul	EUR 369.6

AIRE Rabbit pAb
A14183-200ul	Abclonal	200 ul	EUR 550.8

AIRE Rabbit pAb
A14183-20ul	Abclonal	20 ul	EUR 219.6

AIRE Rabbit pAb
A14183-50ul	Abclonal	50 ul	EUR 267.6

AIRE (isoform 1)
GT41000	Neuromics	100 ug	EUR 568.8

AIRE Blocking Peptide
AF0334-BP	Affbiotech	1mg	EUR 234

AIRE Blocking Peptide
20-abx062024	Abbexa	EUR 326.40 EUR 493.20	1 mg 5 mg

AIRE Blocking Peptide
DF6603-BP	Affbiotech	1mg	EUR 234

AIRE Blocking Peptide
DF3026-BP	Affbiotech	1mg	EUR 234

Rat AIRE ELISA Kit
ERA0534	Abclonal	96Tests	EUR 625.2

AIRE Cell ELISA Kit
abx595022-96tests	Abbexa	96 tests	EUR 764.4

Goat AIRE ELISA Kit
EGTA0534	Abclonal	96Tests	EUR 625.2

Mouse AIRE ELISA Kit
EMA0534	Abclonal	96Tests	EUR 625.2

Sheep AIRE ELISA Kit
ESA0534	Abclonal	96Tests	EUR 625.2

Human AIRE ELISA Kit
EHA0534	Abclonal	96Tests	EUR 625.2

AIRE ELISA KIT|Human
EF005361	Lifescience Market	96 Tests	EUR 826.8

Human AIRE ELISA Kit
ELA-E13302h	Lifescience Market	96 Tests	EUR 988.8

Monkey AIRE ELISA Kit
EMKA0534	Abclonal	96Tests	EUR 625.2

Bovine AIRE ELISA Kit
EBA0534	Abclonal	96Tests	EUR 625.2

Rabbit AIRE ELISA Kit
ERTA0534	Abclonal	96Tests	EUR 625.2

Canine AIRE ELISA Kit
ECA0534	Abclonal	96Tests	EUR 625.2

Porcine AIRE ELISA Kit
EPA0534	Abclonal	96Tests	EUR 625.2

Chicken AIRE ELISA Kit
ECKA0534	Abclonal	96Tests	EUR 625.2

Anserini AIRE ELISA Kit
EAA0534	Abclonal	96Tests	EUR 625.2

Human AIRE shRNA Plasmid
20-abx950227	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Mouse AIRE shRNA Plasmid
20-abx969093	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

AIRE Recombinant Protein (Rat)
RP189656	ABM	100 ug	Ask for price

AIRE Recombinant Protein (Human)
RP046219	ABM	100 ug	Ask for price

AIRE Recombinant Protein (Mouse)
RP115070	ABM	100 ug	Ask for price

Aire ORF Vector (Rat) (pORF)
ORF063220	ABM	1.0 ug DNA	EUR 607.2

Guinea Pig AIRE ELISA Kit
EGA0534	Abclonal	96Tests	EUR 625.2

AIRE ORF Vector (Human) (pORF)
ORF015407	ABM	1.0 ug DNA	EUR 486

Aire ORF Vector (Mouse) (pORF)
ORF038358	ABM	1.0 ug DNA	EUR 607.2

AIRE ELISA Kit (Mouse) (OKCD02354)
OKCD02354	Aviva Systems Biology	96 Wells	EUR 1028.4
Description: Description of target: Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla. Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4+ T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.058 ng/mL

AIRE ELISA Kit (Human) (OKCD08086)
OKCD08086	Aviva Systems Biology	96 Wells	EUR 1170
Description: Description of target: AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript p;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.053ng/mL

Human Autoimmune Regulator (AIRE) Protein
20-abx652629	Abbexa	EUR 693.60 EUR 309.60 EUR 2064.00 EUR 828.00 EUR 510.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Autoimmune Regulator (AIRE) Protein
20-abx652630	Abbexa	EUR 693.60 EUR 309.60 EUR 2064.00 EUR 828.00 EUR 510.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Autoimmune Regulator (AIRE) Protein
20-abx652631	Abbexa	EUR 693.60 EUR 309.60 EUR 2064.00 EUR 828.00 EUR 510.00	100 ug 10 ug 1 mg 200 ug 50 ug

Aire sgRNA CRISPR Lentivector set (Rat)
K6745901	ABM	3 x 1.0 ug	EUR 406.8

AIRE 3'UTR GFP Stable Cell Line
TU050527	ABM	1.0 ml	EUR 1672.8

Aire 3'UTR GFP Stable Cell Line
TU151596	ABM	1.0 ml	Ask for price

Aire 3'UTR GFP Stable Cell Line
TU250439	ABM	1.0 ml	Ask for price

Pig Autoimmune Regulator (AIRE) ELISA Kit
abx360670-96tests	Abbexa	96 tests	EUR 990

Aire sgRNA CRISPR Lentivector set (Mouse)
K4907801	ABM	3 x 1.0 ug	EUR 406.8

AIRE sgRNA CRISPR Lentivector set (Human)
K0063701	ABM	3 x 1.0 ug	EUR 406.8

Rat Autoimmune regulator(AIRE)ELISA kit
YLA1691RA-48T	Shanghai YL Biotech	48T	EUR 465

Rat Autoimmune regulator(AIRE)ELISA kit
YLA1691RA-96T	Shanghai YL Biotech	96T	EUR 600

Anti-AIRE antibody
PAab00241	Lifescience Market	100 ug	EUR 426

Anti-AIRE Antibody
PB9980	BosterBio	100ug/vial	EUR 400.8

Anti-AIRE antibody
STJ116116	St John's Laboratory	100 µl	EUR 332.4
Description: This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Anti-AIRE antibody
STJ22559	St John's Laboratory	100 µl	EUR 332.4
Description: This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Anti-AIRE antibody
STJ70203	St John's Laboratory	100 µg	EUR 430.8

Anti-AIRE antibody
STJ70934	St John's Laboratory	100 µg	EUR 430.8

Anti-AIRE antibody
STJ71077	St John's Laboratory	100 µg	EUR 430.8

Human Autoimmune Regulator (AIRE) CLIA Kit
20-abx493615	Abbexa	EUR 9567.60 EUR 5095.20 EUR 1177.20	10 × 96 tests 5 × 96 tests 96 tests

Mouse Autoimmune Regulator (AIRE) CLIA Kit
20-abx493616	Abbexa	EUR 9567.60 EUR 5095.20 EUR 1177.20	10 × 96 tests 5 × 96 tests 96 tests

Human Autoimmune Regulator (AIRE) CLIA Kit
abx196471-96tests	Abbexa	96 tests	EUR 990

AIRE Colorimetric Cell-Based ELISA Kit
EKC1020	BosterBio	100ul	EUR 686.4

Mouse Autoimmune Regulator (AIRE) ELISA Kit
20-abx153694	Abbexa	EUR 8853.60 EUR 4719.60 EUR 1093.20	10 × 96 tests 5 × 96 tests 96 tests

Human Autoimmune Regulator (AIRE) ELISA Kit
abx250784-96tests	Abbexa	96 tests	EUR 848.4

Human Autoimmune Regulator (AIRE) ELISA Kit
20-abx150773	Abbexa	EUR 8853.60 EUR 4719.60 EUR 1093.20	10 × 96 tests 5 × 96 tests 96 tests

Human Autoimmune Regulator (AIRE) ELISA Kit
abx570732-96tests	Abbexa	96 tests	EUR 848.4

Mouse Autoimmune Regulator (AIRE) ELISA Kit
abx570926-96tests	Abbexa	96 tests	EUR 886.8

Human Autoimmune Regulator (AIRE) ELISA Kit
DLR-AIRE-Hu-48T	DL Develop	48T	EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Autoimmune Regulator (AIRE) in samples from tissue homogenates or other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
DLR-AIRE-Hu-96T	DL Develop	96T	EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Autoimmune Regulator (AIRE) in samples from tissue homogenates or other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
DLR-AIRE-Mu-48T	DL Develop	48T	EUR 632.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Autoimmune Regulator (AIRE) in samples from tissue homogenates or other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
DLR-AIRE-Mu-96T	DL Develop	96T	EUR 825.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Autoimmune Regulator (AIRE) in samples from tissue homogenates or other biological fluids.

Human AIRE/ Autoimmune regulator ELISA Kit
E0100Hu	Sunlong	1 Kit	EUR 726

Human AIRE(Autoimmune regulator) ELISA Kit
EH1501	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Mouse Autoimmune regulator, Aire ELISA KIT
ELI-11972m	Lifescience Market	96 Tests	EUR 1038

Human Autoimmune regulator, AIRE ELISA KIT
ELI-12083h	Lifescience Market	96 Tests	EUR 988.8

Human Autoimmune Regulator (AIRE) ELISA Kit
SEC322Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
SEC322Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
SEC322Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
SEC322Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
4-SEC322Hu	Cloud-Clone	EUR 5738.40 EUR 3031.20 EUR 768.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Autoimmune Regulator (AIRE) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
SEC322Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5834.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
SEC322Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 585.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
SEC322Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 785.28
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
SEC322Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3173.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
4-SEC322Mu	Cloud-Clone	EUR 5895.60 EUR 3114.00 EUR 786.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Autoimmune Regulator (AIRE) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Autoimmune Regulator(AIRE)ELISA Kit
QY-E00071	Qayee Biotechnology	96T	EUR 433.2

Human Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Hu-48Tests	Reddot Biotech	48 Tests	EUR 652.8

Human Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Hu-96Tests	Reddot Biotech	96 Tests	EUR 907.2

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Mu-48Tests	Reddot Biotech	48 Tests	EUR 668.4

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Mu-96Tests	Reddot Biotech	96 Tests	EUR 928.8

Human Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Hu-48Tests	Reddot Biotech	48 Tests	EUR 625.2

Human Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Hu-96Tests	Reddot Biotech	96 Tests	EUR 867.6

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Mu-48Tests	Reddot Biotech	48 Tests	EUR 639.6

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Mu-96Tests	Reddot Biotech	96 Tests	EUR 888

Human Autoimmune regulator(AIRE)ELISA kit
YLA4398HU-48T	Shanghai YL Biotech	48T	EUR 435

Human Autoimmune regulator(AIRE)ELISA kit
YLA4398HU-96T	Shanghai YL Biotech	96T	EUR 562.5

Human Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Hu-48T	Reddot Biotech	48T	EUR 475.34
Description: tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Hu-96T	Reddot Biotech	96T	EUR 679.04
Description: tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Mu-48T	Reddot Biotech	48T	EUR 487.52
Description: tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Mu-96T	Reddot Biotech	96T	EUR 696.47
Description: tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Hu-48T	Reddot Biotech	48T	EUR 452.7
Description: tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Hu-96T	Reddot Biotech	96T	EUR 646.7
Description: tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Mu-48T	Reddot Biotech	48T	EUR 464.3
Description: tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Mu-96T	Reddot Biotech	96T	EUR 663.3
Description: tissue homogenates and other biological fluids.

Monkey Autoimmune Regulator (AIRE) ELISA Kit
abx359019-96tests	Abbexa	96 tests	EUR 990

Rabbit Autoimmune Regulator (AIRE) ELISA Kit
abx363707-96tests	Abbexa	96 tests	EUR 990

AIRE Protein Vector (Rat) (pPM-C-HA)
PV252880	ABM	500 ng	EUR 723.6

Chicken Autoimmune Regulator (AIRE) ELISA Kit
abx355828-96tests	Abbexa	96 tests	EUR 990

AIRE Protein Vector (Rat) (pPB-C-His)
PV252878	ABM	500 ng	EUR 723.6

AIRE Protein Vector (Rat) (pPB-N-His)
PV252879	ABM	500 ng	EUR 723.6

AIRE Protein Vector (Rat) (pPM-C-His)
PV252881	ABM	500 ng	EUR 723.6